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Over time most slot machines have a 10-15% advantage over the player. But you may win some or you may lose some. Considering each spin is random as selected by the rng in theory it doesn't matter but if I hit a good winning spin I tend to move at that point. Stay on the move!
Well, mathematically speaking, there is no difference whether or not you are playing one slot or moving around the casino. Due to the fact that slots are built around RNGs, and the consequence of every spin is totally arbitrary, you'll get the same fate whether you play at one slot the entire day, or move around.