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It gets some things right - for example, people DO usually have anuses, and pooping in open wounds is generally viewed as bad for you - but it also makes some critical errors, like performing mouth-to-butt surgery without the use of ventilation or monitoring equipment.
The Human Centipede films are known for their depraved and disgusting content, but they have also sparked a fascination with body horror. The trilogy was actually inspired by horrific events from Nazi Germany, particularly the experiments conducted by Dr. Josef Mengele.